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In agreement with this concept, the analysis of brains from preclinical AD (PCAD) subjects, who represent an early phase of AD before clinical signs and symptoms appear, led to the identification of oxidized proteins such as HSP90 and Enolase 1, whose alterations might contribute to the transition toward MCI and memory loss (317)

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But the FDA flagged a serious adverse event, including a death, associated with an IV ipamorelin infusion (although it wasn’t clear whether the peptide directly caused the participant's death)

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