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Gut–Brain Signaling in Parkinson's Disease: A Narrative Review

some use oral capsules, though bioavailability is debated

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Common causes of histamine intolerance include: Impaired DAO (diamine oxidase) activity , the enzyme responsible for breaking down histamine in the gut Gut inflammation or leaky gut , which increases histamine absorption Dysbiosis , particularly bacteria that produce histamine Nutrient deficiencies , especially vitamin B6, zinc, and copper imbalance Chronic stress and cortisol dysregulation Estrogen dominance , which slows histamine clearance Environmental triggers , including mold, chemicals, and allergens Many patients labeled with “histamine intolerance” are actually experiencing histamine overproduction combined with impaired clearance , which requires a broader clinical approach