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Patients with renal impairment, renal failure , hepatic disease, diabetes mellitus, systemic lupus erythematosus (SLE), congestive heart failure, rheumatoid arthritis, edema, extracellular volume depletion (i.e., hypovolemia or dehydration), sepsis
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For instance, mixing 2mL of water into a 5mg vial creates a liquid concentration of 2.5mg per milliliter
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