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Budd-Chiari syndrome was perceived as originally suggested[153,154], a hepatic venous outflow obstruction and its manifestation, regardless of cause, but this was mostly attributed to thrombosis, which can be located anywhere from the small hepatic veins to the entrance of the inferior vena cava into the right atrium[153,154]

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It is thus expected that combing monoclonal antibodies and nano-carriers could also improve the efficiency of immunotherapy