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Phase 2 MASLD Substudy (Nature Medicine, 2024): In a substudy of 98 participants with metabolic dysfunction-associated steatotic liver disease (MASLD), retatrutide 12 mg reduced liver fat by 82.4% compared with a 0.3% increase in the placebo group at 48 weeks

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It helps regulate: blood sugar appetite digestion GLP-1 medications (like semaglutide) mimic this hormone—but in a longer-lasting, more powerful way