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Indeed, pretreated LPS/ATP-stimulated macrophages with DTT almost completely abolished GYY4137-induced inhibition of p65 transcriptional activity (Fig

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These findings clearly show that BPC 157 may successfully compete with the initial events in intra-abdominal hypertension (i.e., significant damage to the intestinal epithelium and dilation of intestinal tight junctions, increased mucosal barrier permeability, bacterial translocation, and sepsis (Luetic et al., 2017