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Some situations that may lead patients to ask about B12 shots include: A laboratory result showing low or borderline vitamin B12 Questions about fatigue, weakness, or other symptoms when B12 status may be relevant A history that may make adequate vitamin B12 absorption more difficult Prior oral supplementation that has not maintained levels as expected A need for a physician-guided supplementation schedule and follow-up plan Understanding B12 Shots B12 shots are injections containing vitamin B12