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LNPs were prepared using the ionizable lipid D-Lin-MC3-DMA (MedKoo Biosciences, 555308) and helper lipids distearoylphosphatidylcholine (DSPC) (Avanti Polar Lipids, 850365 C), cholesterol (Avanti Polar Lipids, 700000 P), and DMG-PEG2000 (Avanti Polar Lipids, 880151 P) at a molar ratio of 50:10:38.5:1.5 65
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