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doi: 10.3390/ijms18071545
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Indeed elevated levels of ROS (during radio- or chemotherapy) induced the translocation of Nrf-2 to the nucleus, where it bound to the antioxidant response element (ARE) or the electrophile-response element in the promoter region of Nrf-2, targeting antioxidant and anti-apoptotic genes, including heme-oxygenase 1 (HO-1) (Pan et al., 2013
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