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Among the remaining metabolites, particularly notable are components of purine metabolism, ribose-5-phosphate, and uric acid, demonstrating approximately 4-fold elevation in POAG

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Advances in curcumin derivatives, such as steroidal and dimethylaminomethyl‐substituted analogues, have enhanced neuroprotective efficacy by improving bioavailability and multi‐target engagement, demonstrating dose‐dependent cognitive improvements and inhibition of acetylcholinesterase and Aβ aggregation in animal models (Elmegeed et al