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In keeping with the hypothesis that the interplay within the gut-brain axis is a crucial component in the development of neurodevelopmental disorders, the group also analyzed intestinal epithelial tissue from 12 individuals with ASD and 9 without such disorders
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Key genes showing upregulation during this window include: DDIT4 for metabolic coordination and mTOR regulation SLC25A25 for mitochondrial ATP transport Per1 and Per2 for circadian rhythm coordination Foxo1 for metabolic regulation Alas2 for heme synthesis in skeletal muscle This gene signature closely matches what researchers observe in human quadricep muscle following cycling exercise
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