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In its 48-week Phase 2 trial, Retatrutide achieved a mean weight reduction of up to 24.2% at the highest dose

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Typically, GluN2A- and GluN2B-containing diheteromers manifest large conductances (~50 pS), longer channel open times (3-5 ms), and higher open probabilities (Po, ~0.4-0.5), when compared to GluN2C-or GluN2D-containing diheteromers that exhibit low conductances (~37 pS), shorter channel open times (0.5-1 ms), and lower open probabilities (Po, ~0.01) 31

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