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Significant increase in risk of breast cancer for Asians was found in GSTM1-null genotype ( P =0.012, odds ratio [OR] =1.17, 95% confidence interval [CI] =1.04–1.32) and GSTT1-null genotype ( P =0.039, OR =1.19, 95% CI =1.01–1.41)
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Human studies have predominantly used SPM precursors (e.g., DHA, EPA) or intermediates (e.g., 17-HDHA and 18-HEPE) rather than pre-formed SPMs due to the latter’s poor bioavailability and metabolic instability (119–121)
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