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Thereby, these negative symptoms, approached in the noncompetitive NMDA antagonist ketamine-induced resembling โnegative-likeโ schizophrenia-like symptoms (cognitive dysfunction (novel object recognition test)) [12,13,14], social withdrawal [15,16], anhedonia (sucrose test) [17,18], anxiogenic effect (open field test) [18,19,20,21], clearly constitute an unmet medical need in schizophrenia [5]
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