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So an effective way to stop the formation of 5-alpha reductase (and reducing DHT) is to… Compete with the coenzyme NADPH, or… Block NADPH These are two mechanisms of direct 5-alpha reductase inhibition – or for the lay person – reducing 5-alpha reductase by stopping it from forming
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doi: 10.1016/j.fct.2013.01.055
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