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DOPAdihydroxyphenylalanine DHICA 5,6-dihydroxy indole-2-carboxylic acid DCT Dopachrome tautomerase TRP tyrosinase-related protein MITF microphthalmia-associated transcription factor MAPK Mitogen-Activated Protein Kinase IC50 half-maximal inhibitory concentration TD50 half-maximal toxicity dose μM micromolar ROS reactive oxygen species B16-F10 malignant melanoma cell line of C57BL/6 J mice A375 human melanoma cell line B16BL6 melanoma-associated cell line α-MSH Alpha-Melanocyte-Stimulating Hormone B16 melanoma-associated cell line UVR ultraviolet radiation LPO lipid peroxide USFA unsaturated fatty acids ROS reactive oxygen species CAT antioxidant enzyme catalase GST glutathione-S-transferase BHT 2, 6-di-tert-butyl-p-cresol FRAP ferric ion reducing antioxidant power DPPH 2, 2-diphenyl-1-picrylhydrazyl ABTS 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid EC50 median effective concentration IL interleukin IL-6 Interleukin-6 IL-1β Interleukin-1β COX-2 Cyclooxygenase-2 PGE2 Prostaglandin E2 MMP-1 and MMP-3 Matrix Metalloproteinases-1,-3 TNF-α Tumor Necrosis Factor-α HaCaT human keratinocyte cell line HDFn human dermal fibroblast cells SPF sun protection factor SOD superoxide dismutase GSH-Px glutathione peroxidase MDA malondialdehyde MIC minimum inhibitory concentration MBC minimum bactericidal concentration DIZ diameter of inhibition zone TNF tumor necrosis factor LPS lipopolysaccharide DSS dextran sulfate sodium PGE prostaglandin E COX cyclooxygenase TLR toll-like receptor p-HBA methyl p-hydroxybenzoate BuP butyl p-hydroxybenzoate chlorobenzyl etherSBsodium benzoate ATP adenosine triphosphate ADP adenosine diphosphate G+ Gram-positive bacteria G- Gram-negative bacteria ZOI zone of inhibition MIC minimum inhibitory concentration MBC minimum bactericidal concentration E

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