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In line with this evidence of the beneficial effects of vitamin B12 in individuals without or with mild cognitive impairments, a recent randomized controlled trail reported that the combination of oral vitamin B12 (25 µg) and folic acid (800 µg) for six months reduced the levels of peripheral inflammatory cytokines and improved cognitive performance significantly in MCI patients, assessed by the measurement of the full-scale intelligence quotient (IQ), verbal IQ as well as information and digit span scores
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That improves safety and helps ensure the medication reaches muscle (rather than subcutaneous fat), which supports predictable absorption
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