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Mechanistically, NNMT suppression increased adipose SAM and NAD⁺, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]
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Specifically, researchers examined the effects of intra-articular injections of AOD9604, both alone and in combination with HA, on cartilage morphology, histopathology, and functional outcomes such as lameness
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