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As outlined earlier, GSTP exists as four functional allelic variants in humans: wild-type GSTP1*A (Ile105/Ala114), GSTP1*B (Val105/Ala114), GSTP1*C (Val105/Val114) and GSTP1*D (Ile105/Val114) [39] with GSTP1*B and GSTP1*C having lower catalytic activity than GSTP1*A [40]
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Although the results are highly variable in animal models, evidence indicates that arsenic could impair adipose tissue physiology and cause changes in body weight and adiposity depending on diet, arsenic concentration, and the age of exposure
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