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In RE rats, activation of the NF-κB pathway was found to result in the release of large amounts of TNF-α and IL-6 (63)
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J Leukoc Biol 66:733–739 [DOI] [PubMed] [Google Scholar] Romao VC, Lima A, Bernardes M, Canhao H, Fonseca JE (2014) Three decades of low-dose methotrexate in rheumatoid arthritis: can we predict toxicity
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