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This, in turn, further disrupts GBA activity by hindering its trafficking from the endoplasmic reticulum to the Golgi to lysosomes, ultimately contributing to neurodegeneration [117]
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5 Mitochondrial ROS imbalance in the molecular pathogenesis of supraspinatus muscle atrophy 5.1 Oxidative stress-induced damage triggered by ROS imbalance 5.1.1 Oxidative modification of proteins, lipids, and DNA Reactive oxygen species (ROS) induce oxidative damage to skeletal muscle macromolecules, disrupting structural integrity and biological function
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