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Excessive NAM depletion directly reduces the substrate supply for NAD+ synthesis, leading to decreased intracellular NAD+ levels

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But when a human gets sick…we take the people out of the tank, mess with the people, and put them back in the tank, and we’re like, ‘Why do you keep getting sick?’ We never think about cleaning the tank!” Later, while we are doing a short three-mile run around a nearby park wearing 12-pound weighted vests, I ask Brecka, out of curiosity, how much his electric bill is