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For example, a group at the University of Oulu conducted a 5-year prospective, placebo-controlled study on 49 children following exposure to paracetamol ( n = 19) or to saline control ( n = 20) [39]
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Lastly, Skin conditions such as eczema, psoriasis, and certain allergies can lead to the darkening of the skin on the knuckles
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