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IGF-1 has also been implicated in the expression of immunosuppressive cytokines including interleukin-10 [217, 218], as well as induction of the M2 phenotype of macrophages [219]
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The transcriptional enhanced associate domain (TEAD) family members are the major transcription factors to which YAP and TAZ bind, leading to expression of Hippo target genes involved in cell growth, proliferation, migration, and survival (10, 11)
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