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In particular, we used a series of ISH probes targeting the well-known marker genes for different stages of OL lineage cells such as Pdgfra, Plp, Mbp, Mog, as well as a recently reported maker for newly forming/formed OLs, namely Enpp6 , to access a reliable counting of these cells
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Proliferative capacity and production of IL-2 are lost first, followed by the ability to produce TNFα, and ultimately to produce IFNγ [7,68]
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