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In clinical studies, treatment with recombinant IGF-1 improved renal function in patients with moderate renal insufficiency or end stage renal disease (ESRD), as evidenced by increased GFR, lower plasma creatinine and BUN levels, and enhanced inulin clearance

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This trend reflects a fundamental shift in the global nutritional paradigm, where consumers no longer seek foods with only basic nutritional value, but prefer products with dual functionality—nutritional and physiological—that can support cardiometabolic, immune, or cognitive health [447,448]

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