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7 Recent advances and clinical trials for neurodegenerative diseases 7.1 NP-based siRNA delivery for ADs The instability of siRNA therapy in the circulation and the fact that it is unable to reach target cells in the central nervous system (91, 92) because of the BBB poses the biggest hurdle in siRNA therapy
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The inventors have also discovered that NNMT inhibitors may be used to inhibit NNMT and to treat related diseases or conditions
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