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Depletion of cellular GSH, ranging between 61 and 88%, had a differential effect on the sensitivity to PtII vs PtIV drugs in the three cell lines: cytotoxicity of the PtIV drugs, tetraplatin and CHIP, was substantially enhanced in both the resistant and sensitive cell lines

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Based on the above studies and the data shown here, we suggest that Immunocal might hold significant potential as a novel therapeutic approach to bolster GSH levels in neurodegenerative disorders for which the underlying pathology involves significant oxidative stress

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