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Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53 and is hypothesized to act through a membrane-mediate mechanism [104] Curcumin has also been shown to block the NF-kappaB cell survival pathway and suppress the apoptotic inhibitor, x-linked inhibitor of apoptosis protein (XIAP)
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Despite these benefits, long-term LC administration has been associated to cardiovascular risks due its conversion to trimethylamine- N -oxide (TMAO) by the gut microbiota
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