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Onivyde, in combination with fluorouracil and leucovorin, was first approved in 2015 for patients who had progressed after treatment with gemcitabine
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Recent advances in formulations such as lipid-based systems, polymeric micelles, β-cyclodextrin-metal-organic frameworks (MOF), and luteolin prodrugs have shown considerable promise in enhancing solubility, oral bioavailability, metabolic stability, and tissue exposure (Liu et al., 2021
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